A Short Review of Honey Supplementation on Bone Metabolism Markers and Sports Performance

Chee Ping Fadzel Wong.

Transactions on Science and Technology, 8(3-2), 184 - 190.

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ABSTRACT
Bee product such as honey has been used thousands of years ago as a healthy supplement among human being. Honey is a nutritious supplement and contains fructose, glucose amino acids and multivitamins-minerals. It is well documented that honey has antioxidant, anti-inflammatory, antimicrobial and anti-mutagenic properties. An antioxidant agent is proven able to prevent several acute and chronic disorders such as inflammatory, osteoporosis, osteoarthritis, cardiovascular and cancer. It is believed that honey is beneficial on bone health and sports performance but it is lacking solid scientific evidences to prove its efficacy. This article summarizes current evidences on the effects of honey supplementation on bone metabolism markers and sports performance.

KEYWORDS: Honey; Exercise; Bone metabolism markers; Antioxidant; Sports performance



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REFERENCES
  1. Abbey, E.L. & Rankin, J.W. 2009. Effect of ingesting of honey sweetened beverage on soccer performance and exercise induced cytokine response. International Journal of Nutrition and Metabolism, 19, 659-672.
  2. Abouda, Z., Zerdani, I., Kalalou, I., Faid, M. & Ahami, M.T. 2011. The antibacterial activity of Moroccan bee bread and bee-pollen (fresh and dried) against pathogenic bacteria. Research Journal of Microbiology, 6, 376-384.
  3. Ahmad, N.S., Ooi, F.K., Ismail, M.S. & Mohamed, M. 2015. Effects of post-exercise honey drink ingestion on blood glucose and subsequent running performance in the heat. Asian Journal of Sports Medicine, 6, 1-8.
  4. Ahmed, S., Sulaiman, S. A., Baig, A.A., Ibrahim, M., Liaqat, S., Fatima, S., Jabeen, S., Shamin, N. & Othman, N.H. 2018. Honey as a potential natural antioxidant medicine: an insight into its molecular mechanisms of action. Oxidative Medicine and Cellular Longevity, 10, 1-19.
  5. Aljadi, A.M. & Kamaruddin, M.Y. 2004. Evaluation of the phenolic contents and antioxidant capacities of two Malaysian floral honeys. Food Chemistry, 85(5), 513–518.
  6. Al-Mamary, M., Al-Meeri, A. & Al-Habori, M. 2002. Antioxidant activities and total phenolic of different types of honey. Nutrition Research, 22, 1041–1047.
  7. Al-Waili, J.N.S. 2003. Effects of daily consumption of honey solution on hematological indices and blood levels of minerals and enzymes in normal individuals. Journal of Medicinal Food, 6 (2), 135–140.
  8. Aly, M.O., Elgohary, R. & Tayel, D.I. 2019. The effect of honey supplementation formula on delaying some fatigue markers on 1500 meters runners. International Journal of Sports Science, 9, 47-53.
  9. Ariefdjohan, M.W., Martin, B.R., Lachcik, P.J. & Weaver, C.M. 2008. Acute and chronic effects of honey and its carbohydrate constituents on calcium absorption in rats. Journal of Agricultural and Food Chemistry, 56(8), 2649–2654.
  10. Aryappalli, P., Shabbiri, K., Masad, R., Al-Marri, R.H., Haneefa, S.M., Mohamed, Y.A., Attoub, S., Marques, O., Ramadi, K.N., Cabezudo, M.J. & Ramadi, B.K. 2019. Inhibition of tyrosine-phosphorylated STAT3 in human breast and lung cancer cells by Manuka honey is mediated by selective antagonism of the IL-6 receptor. International Journal of Molecular Sciences, 20, 1-21.
  11. Bogdanov, S., Jurendic, T., Sieber, R. & Gallmann, P. 2008. Honey for nutrition and health: A review. Journal of the American College of Nutrition, 27, 677–689.
  12. Chepulis, L. & Starkey, N. 2008. The long term effects of feeding honey compared with sucrose and a sugar free diet on weight gain, lipid profiles, and DEXA measurements in rats. Journal of Food Science, 73, 1–7.
  13. Cooper, R.A., Molan, P., Krishnamoorthy, L. & Harding, K. 2001. Manuka honey used to heal a recalcitrant surgical wound. European Journal of Clinical Microbiology and Infection Disease, 20, 758–759.
  14. Dekkers, J.C., Van Doornen, L.J. & Kemper, H.C. 1996. The role of antioxidant vitamins and enzymes in the prevention of exercise-induced muscle damage. Sports Medicine, 21(3), 213-238.
  15. Domazetovic, V., Marcucci, G., Lantomasi, T., Brandi, M.L. & Vincenzini, M.T. 2017. Oxidative stress in bone remodelling: role of antioxidant. Clinical Cases in Mineral and Bone Metabolism, 14(2), 209-216.
  16. Earnest, C.P., Lancaster, S.L., Rasmussen, C.J., Kerkisck, C.M., Lucia, A., Greenwood, M.C., Almada, A.L., Cowan, P.A. & Kredier, R.B. 2004. Low versus high glycemic index carbohydrate gel ingestion during stimulated 64 km cycling time trial performance. Journal of Strength and Conditioning Research, 18, 466-472.
  17. Erejuwa, O.O., Sulaiman, S.A. & AbWahab, M.S. 2012. Honey: A novel antioxidant. Molecules, 17, 4400–4423.
  18. Ferreres, F., Ortiz, A., Silva, C. & Garcia-Viguera, C. 1992. Flavonoids of La Alcarria honey: A study of their botanical origin. International Journal of Food Research and Technology, 194, 139–143.
  19. Hajizadeh, M.B., Tartibian, B., Mooren, F.C., Kruger, K., FitzGerald, L.Z. & Chehrazi, M. 2016. A randomized controlled trial examining the effects of 16 weeks of moderate-to-intensive cycling and honey supplementation on lymphocyte oxidative DNA damage and cytokine changes in male road cyclists. Cytokine, 88, 222–231.
  20. Hertog, M.G., Feskens, E.J. & Hollman, P.C. 1993. Dietary antioxidant flavonoids and risk of coronary heart disease: the zutphen elderly study. Lancet, 342, 1007-1011.
  21. Kamaruzzaman, M.A., Chin, K.Y. & Ramli, E.S. 2019. A review of potential beneficial effects of honey on bone health. Evidence-Based Complementary and Alternative Medicine, 10(1), 1-10.
  22. Lusby, P.E., Coombes, A.L. & Wilkinson, J.M. 2005. Bactericidal activity of different honeys against pathogenic bacteria. Archives of Medical Research, 36(5), 464–467.
  23. Mosavat, M., Ooi, F.K. & Mohamed, M. 2014. Effects of honey supplementation combined with different jumping exercise intensities on bone mass, serum bone metabolism markers and gonadotropins in female rats. BMC Complementary and Alternative Medicine, 14, 1-8.
  24. Nadia, M.E., Norazlina, M., Norliza, M., Isa, N. & Ahmad, N.S. 2012. Review article: The effects of Tualang honey on bone metabolism of postmenopausal women. Evidence-Based Complementary and Alternative Medicine, 1, 1-7.
  25. Nagai, T., Sakai, M., Inoue, R., Inoue, H. & Suzuki, N. 2001. Antioxidative activities of some commercially honeys, royal jelly and propolis. Food Chemistry, 75, 237-240.
  26. Nayaka, N.M.D., Fidrianny, I., Rika, S. & Singgih, M. 2020. Antioxidant and antibacterial activities of multiflora honey extracts from the Indonesian Apis cerana bee. Journal of Taibah University Medical Sciences, 15(3), 211–217.
  27. Ooi, F.K., Ismail, N.S. & Abdullah, M.Y. 2011. Effects of combined aerobic dance exercise and honey supplementation on bone turnover markers in young females. Asian Journal of Exercise and Sports Science, 8(1), 53-63.
  28. Orrenius, S., Gogvadze, V. & Zhivotovsky, B. 2007. Mitochondrial oxidative stress: implications for cell death. Annual Review of Pharmacology and Toxicology, 47, 143-183.
  29. Rakha, M.K., Nabil, Z.I. & Hussien, A.A. 2008. Cardioactive and vasoactive effects of natural wild honey against cardiac malperformance induced by hyperadrenergic activity. Journal of Medicinal Food, 11(1), 91-98.
  30. Rao, L.G & Rao, A.V. 2013. Oxidative stress and antioxidants in the risk of osteoporosis—role of the antioxidants lycopene and polyphenols. Topics in Osteoporosis, 5, 117–144.
  31. Schneider, M., Coyle, S., Warnock, M., Gow, I. & Fyfe, L. 2013. Anti-microbial activity and composition of manuka and portobello honey. Phytotherapy Research, 27, 1162–1168.
  32. Sen, A. (1995). Oxidants and antioxidants in exercise. Journal of Applied Physiology, 79(3), 675-686.
  33. Seung, H.P., Young, K.K., Moon, S.K. & Seung, H.L. 2020. Antioxidant and antibacterial properties of Hovenia (Hovenia dulcis) monofloral honey produced in South Korea. Food Science and Animal Resources, 40(2), 221-230.
  34. Sherlock, O., Dolan, A. & Athman, R. 2010. Comparison of the antimicrobial activity of Ulmo honey from Chile and Manuka honey against methicillin-resistant Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa. BMC Complementary and Alternative Medicine, 10, 321-328.
  35. Shukri, N., Ooi, F.K., Chen, C.K. & Sirajudeen, K.N.S. 2011. Effects of acacia honey drink supplementation compared to sports drink on blood glucose and running performance in the heat. Proceedings of 16th National Conference on Medical and Health Sciences. 22-23 June 2011, Kelantan, Malaysia. pp 201-205.
  36. Swellam, T., Miyanaga, N. & Onozawa, M. 2003. Antineoplastic activity of honey in an experimental bladder cancer implantation model: in vivo and in vitro studies. International Journal of Urology, 10, 213–219.
  37. Tartibian, B. & Maleki, B.H. 2012. The effects of honey supplementation on seminal plasma cytokines, oxidative stress biomarkers and antioxidants during 8 weeks of intensive cycling training. Journal of Andrology, 3, 449-461.
  38. Tavafzadeh, S.S., Ooi, F.K., Krasilshchikov, O. & Sulaiman, S.A. 2011. Effect of a combination of jumping exercise and honey supplementation on the mass, strength and physical dimensions of bones in young female rats. Journal of ApiProduct and ApiMedical Science, 3(1), 26-32.
  39. Tomasin, R., Pascoal, A.C.R.F., Salvador, M.J. & Gomes-Marcondes, M.C.G. 2020. Aloe vera and honey solution and their ethanolic extraction solution could act on metastasis-regulating processes in walker 256 tumor tissues in vivo? Nutrition and Cancer, 1, 1-9.
  40. Wang, X.H., Andrae, L. & Engeseth, N.J. 2002. Antimutagenic effect of various honeys and sugars against Trp-p-1. Journal of Agricultural and Food Chemistry, 50(23), 6923–6928.
  41. Yang, X.P., Guo, D., Zhang, J.M. & Wu, M.C. 2007. Characterization and antitumor activity of pollen polysaccharide. International Immunopharmacology, 7, 401-408.
  42. Zahan, O.M., Serban, O., Gherman, C. & Fodor, D. 2020. The evaluation of oxidative stress in osteoarthritis. Medicine and Pharmacy Reports, 93(1), 12-22.
  43. Zaharil, M.S., Sulaiman, S.A., Halim, A.S., Jumaat, M.Y.S. & Jaafar, H. 2011. The efficacy of Tualang honey in comparison to silver in dressing wounds in rats. Journal of ApiProduct and ApiMedical Science, 3, 45-53.
  44. Zhou, Q.Z., Li, Zhu, Zhang, D.F., Li, N., Li, Q., Dai, P.P., Mao, Y.X., Li, X.M., Ma, J.F. & Huang, S.B. 2016. Oxidative stress-related biomarkers in postmenopausal osteoporosis: a systematic review and meta-analyses. Disease Markers, 2, 1-12.