Abstract and References
Transactions on Science and Technology Vol. 4, No. 3-3, 402 - 407, 2017

Antibacterial Activity of Surfactin Produced by Bacillus subtilis MSH1

Mohd Hafez Mohd Isa, Mohammed Abdel-Hafiz Faisal Shannaq, Najwa Mohamed, Abdul Rahman Hassan, Najeeb Kaid Nasser Al-Shorgani, Aidil Abdul Hamid
ABSTRACT
 Surfactin is one of the most powerful lipopeptide biosurfactants produced by various strains of Bacillus subtilis, having exceptional surface activity as well as antiviral, antibacterial and antitumor properties. In this study, fermentations in shake flasks were conducted to assess the ability of B. subtilis MSH1 to produce surfactin in Cooper’s media. Investigation of antibacterial activity of surfactin against Shigella dysenteriae and Staphylococcus aureus by using well diffusion method, minimum inhibitory concentration (MIC) and Minimum bactericidal concentration (MBC) shows surfactin having potent bacteriostatic and bactericidal properties which potentially could be utilized for commercial antibiotic formulations with medical and pharmaceutical purposes.
KEYWORDS: Bacillus subtilis; Surfactin; Minimum inhibitory concentration; Minimum bactericidal concentration (MBC)
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