Abstract and References
Transactions on Science and Technology Vol. 4, No. 3-3, 372 - 383, 2017

An Evaluation of Antioxidant and Antidiabetic Potential of Cynometra cauliflora (Nam-nam, Fabaceae)

Azalina Farina Abd Aziz, Md. Safiul Alam Bhuiyan, Mohammad Iqbal
ABSTRACT
 Oxidative damage of biomolecules is implicated in the pathogenesis of various chronic diseases including diabetes. This has led to intensive investigation aimed at reducing the extent of such oxidative injury. Cynometra cauliflora or normally known as “Nam-nam” is a native of Malaysia, grown mainly in northern peninsular Malaysia and possesses many medicinal values in treating several diseases and for health care maintenance. However, antidiabetic and antioxidative potential of C. cauliflora have not been fully investigated. Therefore, the present study was aimed to evaluate the antioxidative, hypolipidemic and hypoglycemic potentials of C. Cauliflora extract against alloxan induced diabetes rats. Treatment of rats with alloxan resulted in a significant increase (P<0.05) level of blood glucose, total cholesterol and low density lipoprotein. On the other hand, oxidative stress was noticed in pancreatic tissue as evidenced by a significant decrease in glutathione level, catalase activity, and also significant increase in malondialdehyde when compared to normal saline control group. Pancreases were examined by hematoxylin and eosin staining. Additionally, serum biochemistry and oxidative stress markers were consistent with the pancreatic histopathological studies. Treatment of diabetic rats with C. Cauliflora extract significantly prevented these alterations and attenuated alloxan-induced oxidative stress. The results of the present study indicated that the hypolipidemic and hypoglycemic potentials of C. Cauliflora might be ascribable to its antioxidant and free radical scavenging properties. Thus, it concluded that C. Cauliflora may be helpful in the prevention of diabetic complications associated with oxidative stress.

 KEYWORDS: Cynometra cauliflora; Nam-nam; Antidiabetic; Antioxidant activity; Oxidative stress
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